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Strohm et al., 1995

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Initially, a single dose of 10 g/kg (absolute dose range 0.71.2 mg) was administered to six subjects (three with severe RI and three with ESRD) but, based on the frequency and severity of gastrointestinal adverse effects, the 10 g/kg dose was not considered a tolerable starting dose

Cappariloside A also possesses antiviral activity, decreases the level of phosphorylated STAT1 in cells, inhibits the replication of influenza viruses H1N1 , H3N2 , PIV3 and ADV , and downregulates the expression of IL-6 , IP-10 , MIG , RANTES/CCL-5 , IFN- and IL-29